Luisa Derouen was a member of her founding congregation, the Eucharistic Missionaries of St. Dominic, for 48 years. In 2009, they and seven other congregations became the Dominican Sisters of Peace. With a graduate degree in liturgy and credentials in spiritual direction, until the 1980s she ministered primarily in rural parishes in religious education and pastoral ministry. She began to minister among the transgender community in 1999 and has been a spiritual companion formally and informally to about 250 transgender people across the country. She is now semiretired at the St. Catharine Motherhouse in central Kentucky.